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The Organ-on-a-chip Experience
During this workshop the participating companies will give visitors the opportunity to take a closer look on a variety of technologies in the field of organ-on-a-chip including technology platforms, tissue models, cell test equipment etcetera.
The following companies will give you an insight in the newest technologies in the field of organ-on-a-chip:
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hDMT
The amazing possibilities of organ-on-a-chip technology During the ‘Organ on a Chip’ workshop hDMT partners will demonstrate current possibilities in the field of organ on a chip technology. These include real-life versions of organ on chip device prototypes that have been developed and used at the University of Twente for studying cardiovascular disease. Movies and hand-outs will be available to give an in-depth overview of how the devices are used and how cells are integrated in these microtechnological systems, resulting in beating heart on a chip, and healthy and diseased blood vessels on a chip. In addition, the organ on chip technology that has been developed at Eindhoven University of Technology for two other applications will be shown: (1) Understanding the development of cancer, and in particular the influence of the mechanical properties and cues of the tumor micro-environment on tumor invasiveness and metastatic behavior. 2) Creating realistic in vitro models of the brain by combining microfluidics and tissue engineering to create a platform that gives insight into both normal and disease-state functioning of the brain. Various devices can be seen as well as how they are designed, fabricated and used. |
Kirkstall
Kirkstall has developed a modular perfusion based system that enables organotypic cell culture and co-culture of cells , tissues or organoids to provide a physiologically relevant model of human metabolic function. Kirkstall provides cell culture chambers, tubing ,pumps and all the ancilliary components needed to control cell culture and carry out in vivo cell monitoring or end point assays. The system is suitable for research into toxicity and safety as well as studies into disease and efficacy of treatments. It also provides a valuable prototyping tool on the way to the future organ and human on a chip devices. It allows development of protocols , selection of suitable media and assay techniques prior to the full micro miniaturisation. Out-of-the-box experimenting with multiple cell types and tissue samples
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Micronit
Micronit is a world leader in microfluidic products that are developed and manufactured for life sciences, medical devices, chemistry, biomedical and industrial applications. We combine our microfluidics expertise and semi-conductor, MEMS and micromachining capabilities to develop and produce innovative solutions for MEMS and microfluidic applications, such as Lab-on-a-Chip (LOAC) & Organ-on-a-Chip (OOC) devices. Together with key-partners in centers of excellence of R&D we design, prototype and co-develop the next generation platform technology for Organ-on-a-Chip applications that are tailored to in vitro mimicking the micro-physiology and morphology of human organs and organoids. Gut-on-a-chip flow system for improved modelling in bioavailability and biotransformation studies
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The hDMT institution (Institute for human Organ and Disease Model technologies) is a precompetitive non-profit technological R&D institution, situated in the Netherlands. This institute integrates state-of-the-art human stem cell technologies with lop level engineering, physics, chemistry, biology, clinical and pharmaceutical expertise from academia and industry to develop and valorise human organ and disease models-on-a-chip.
The Quasi Vivo system is an out-of-the-box tool that is easy to assemble and can be modified to set up experiments with multiple cell types or tissue samples. The process of connecting up a flow system from scratch will be illustrated using several of the standard chambers available from Kirkstall.
A demonstration is provided of a developed microfluidic Gut-on-a-Chip flow system to enable improved modeling in bioavailability and biotransformation studies. The demonstrated R&D prototype based on a resealable double perfusion flowcell with a custom integrated Transwell-equivalent membrane is commercially available through Micronit Microfluidics and is co-developed by RIKILT-Wageningen UR. A comprehensive insight into the total workflow and system setup will be given and explained by the makers and end-users.